Regulation of neuronal functions by the E3-ubiquitinligase Protein Associated with MYC (MYCBP2)

Figures & data

Figure 1 Schematic of the MYCBP2/p38MAPK signaling pathway regulating receptor internalizations. MYCBP2 and its ortholog RPM-1 inhibit the p38 MAPK cascade by targeting MAP3K12 for proteosomal degradation. Activated p38 MAPK prevents the internalization of the TRPV1 at nociceptors of mice, while facilitates at central interneurons of C. elegans the internalization of AMPA receptors.

Table 1 Viability of MYCBP2-knockout animals

Species	Tissue	Viability	Reference
C. elegans	ubiquitous	viable	22, 23
D. melanogaster	ubiquitous	viable	27
D. rerio	ubiquitous	lethal	28
M. musculus	ubiquitous	lethal	24, 26
	neuronal	lethal	25
	Motor neurons	partially viable	24
	Sensory neurons	viable	25

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