Figures & data
Figure 1 Leading processes of radially migrating neurons are anchored to the marginal zone of the cortex. (A) DiI labeling shows that late generated neurons extend their leading processes towards the pial surface. (B) Double immunostaining for p-cofilin (green) and Reelin (red) labels the leading processes of late generated neurons in superficial cortical layers and Reelin-synthesizing Cajal-Retzius cells in the marginal zone. Reelin-synthesizing Cajal-Retzius cells are not labeled for p-cofilin. Scale bars, 40 µm.
Figure 2 Reelin-induced phosphorylation of n-cofilin involves ApoER2 and VLDLR. In cortical lysates prepared from E18 wild-type mice and treated with recombinant Reelin the protein levels of phosphorylated cofilin (p-cofilin) are much higher when compared to those from ApoER2-/- mice. Levels of p-cofilin were only slightly reduced in VLDLR-/- tissue. Actin was used as a loading control.
