Figures & data
Figure 1 Schematic model of the neural relay originating in the liver (for details see text). Hepatic ERK activation associated with obesity results in pancreatic β cell proliferation, via the neuronal system consisting of afferent and efferent nerves and the central nervous system. When applied to mouse models of insulin-deficient diabetes, activation of this neural relay normalized blood glucose. This inter-organ system may serve as a valuable therapeutic target for diabetes by regenerating pancreatic β cell mass.
