Figures & data
Figure 1. A model of the dual functions of Bach1 during interphase and metaphase of the cell cycle. (A) Bach1 occupies MARE enhancers to repress transcription under normal conditions. The elimination of the Bach1-mediated transcriptional repression occurs through inhibition of its DNA binding activity and subsequent Crm1-dependent nuclear export in response to oxidative stress. (B) The kinetochore localization of Crm1 mediates the exclusion of Bach1 from mitotic chromosomes and may be required for the kinetochore recruitment of RanBP2 and RanGAP1. We hypothesize that the misalignment of mitotic chromosomes due to Bach1 depletion might involve an improper kinetochore localization of RanGAP1, RanBP2 and/or Crm1.
