AMPK

Figures & data

Table 1. Overview of ion channels affected by AMPK activation. Shown is a list of the ion channels reported to date to respond to AMPK activation. It is summarized how AMPK activation affects the individual ion channels and what the molecular background for the observed regulation is

Inhibitory effects of AMPK
Ion channel	AMPK effect	Mode of action	References
BKCa	Reduction in current amplitude	Direct channel phosphorylation	^23
CFTR	Decreased open probability	Direct channel phosphorylation (S768)	^20 ^, ^19 ^, ^21
ENaC	Reduction in cell surface expression	Activation of Nedd4–2-mediated endocytosis	^29 ^, ^28
KCa3.1	Reduction in current amplitude	?	^27
Kir2.1	Reduction in cell surface expression	Activation of Nedd4–2-mediated endocytosis	^33
Kir6.2	Reduction in current amplitude	Direct channel phosphorylation (S385)	^45 ^, ^44
Kv7.1	Reduction in cell surface expression	Activation of Nedd4–2-mediated endocytosis	^32 ^, ^31 ^, ^34
TASK-3	Reduction in current amplitude	?	^25
TREK-1	Reduction in current amplitude	Involves the phosphorylation sites S300 and S333	^26
TREK-2	Reduction in current amplitude	Involves the phosphorylation sites S326 and S359	^26
Stimulatory effects of AMPK
Ion channel	AMPK effect	Mode of action	References
Kir6.2	Increased open probability	?	^40
Kir6.2	Increased surface expression	?	^43 ^, ^42
Kv2.1	Hyperpolarizing shifts in the current-voltage relationship for channel activation and inactivation	Direct channel phosphorylation (S440)	^38
Nav1.5	Slowing of open-state inactivation and a hyperpolarizing shift in the voltage-activation curve	?	^37

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