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Review

Organelle biogenesis and interorganellar connections

Better in contact than in isolation

&
Article: e29587 | Received 13 Jun 2014, Accepted 15 Jun 2014, Published online: 23 Jun 2014

Figures & data

Figure 1. Schematic representation of membrane contact sites and their functions. Organelle dynamics indicates both the shape and motility of involved organelles. For LD and Pex, which are believed to originate from the ER, the role of direct contacts observed with this compartment remains unclear and may be implicated in lipid transfer between the ER and the mature form of the organelles.Citation78,Citation79 ER, endoplasmic reticulum; Pex, peroxisomes; LD, lipid droplets; Mito, mitochondria; Melano, melanosomes; Golgi, Golgi apparatus; EE, early endosomes; LE, late endosomes; MVBs, multivesicular bodies; Lyso, lysosomes; ILV, intraluminal vesicles.

Figure 1. Schematic representation of membrane contact sites and their functions. Organelle dynamics indicates both the shape and motility of involved organelles. For LD and Pex, which are believed to originate from the ER, the role of direct contacts observed with this compartment remains unclear and may be implicated in lipid transfer between the ER and the mature form of the organelles.Citation78,Citation79 ER, endoplasmic reticulum; Pex, peroxisomes; LD, lipid droplets; Mito, mitochondria; Melano, melanosomes; Golgi, Golgi apparatus; EE, early endosomes; LE, late endosomes; MVBs, multivesicular bodies; Lyso, lysosomes; ILV, intraluminal vesicles.