Cytoplasmic microtubule sliding

Figures & data

Figure 1 Molecular motors organize microtubules to facilitate microtubule-mediated force production. (A) The mitotic spindle is organized by three motor proteins and drives the separation of chromosomes into daughter cells. The motors include the dynein/dynactin complex, which functions to anchor the centrosomes to the cell cortex (a), and anchor microtubule minus ends to the centrosome (b). The kinesin 5 motor (c) pushes the two centrosomes apart by crosslinking and sliding anti-parallel microtubules. (B) Our recent study shows that the growth of cellular processes filled with microtubule bundles (d) is powered by microtubule sliding by kinesin-1 heavy chain (e) in interphase cells.23

Jolly AL, Kim H, Srinivasan D, Lakonishok M, Larson AG, Gelfand VI. Kinesin-1 heavy chain mediates microtubule sliding to drive changes in cell shape. Proc Natl Acad Sci USA 2010; 107:12151 - 12156

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