Figures & data
Figure 1 A proposed model for TRPV4-dependent clustering of AJ complexes. In the absence of extracellular Ca2+ (0 Ca2+), keratinocytes do not contact each other. After addition of high extra-cellular Ca2+, adhesion molecules relocate to the plasma membrane. TRPV4 binds to β-catenin, making complexes with adhesion molecules. Under physiological skin temperature, Ca2+ influx via TRPV4 promotes Rho activation, which enhances actin polymerization at cell-cell contact sites. Clustering of AJ complexes is promoted adjacent to TRPV4, leading to maturation of intercellular junction.
![Figure 1 A proposed model for TRPV4-dependent clustering of AJ complexes. In the absence of extracellular Ca2+ (0 Ca2+), keratinocytes do not contact each other. After addition of high extra-cellular Ca2+, adhesion molecules relocate to the plasma membrane. TRPV4 binds to β-catenin, making complexes with adhesion molecules. Under physiological skin temperature, Ca2+ influx via TRPV4 promotes Rho activation, which enhances actin polymerization at cell-cell contact sites. Clustering of AJ complexes is promoted adjacent to TRPV4, leading to maturation of intercellular junction.](/cms/asset/fe98225e-ad45-4879-a517-9ec3a0722a45/kcib_a_10913461_f0001.gif)