Effect of follow-up time on the relation between prediagnostic serum 25-hydroxyvitamin D and all-cause mortality rate

Figures & data

Figure 1. Correlation coefficient of serum 25(OH)D concentration measured in two periods vs. follow-up period.

Figure 2. Hazard ratios (HRs) for all-cause mortality rate per 20-nmol/l increase in serum 25(OH)D concentration, using data from Figure 3 in Schöttker et al.13 vs. follow-up period. The equations for the regression fits are: HR = 0.72 + 0.017 t; HR [lower confidence interval (CI) = 0.50 + 0.029 t]; HR (upper CI) = 1.03 – 0.0009 t, where t = time (years).

Table 1. Correlations between serum 25(OH)D concentrations measured at different intervals

Location	Mean age at first measurement (years)	Interval (years)	Pearson coefficient	Spearman rank coefficient	Ref.
U.S.	61	1		0.65	31
Denmark	64	1	0.59, 0.77	0.56, 0.74	32*
Denmark	64	2	0.56	0.55	32*
Denmark	64	3	0.72	0.67	32*
U.S.	59	3	0.70		33
Denmark	64	4	0.70	0.64	32*
U.S.	61	4		0.61	31
Denmark	64	5	0.54	0.49	32*
U.S.	61	5		0.53	31
Norway	52.5	14	0.42		34

* Personal communication from L. Rejnmark in addition to published data.

Table 2. Statistics for the all-cause mortality rate data used in this study¹³

Hazard ratio	Lower limit	Upper limit	Follow-up period (years)	Ref.
0.943	0.856	1.039	6.0	35
0.634	0.409	0.983	6.2	36
0.816	0.684	0.975	6.5	37
0.999	0.842	1.186	7.3	38
0.791	0.615	1.018	8.0	39
0.909	0.862	0.959	8.7	40
0.787	0.643	0.963	9.1	41
0.870	0.761	0.995	10.0	42
0.930	0.830	1.042	11.7	43
1.007	0.925	1.096	12.7	44
0.923	0.859	0.992	13.5	45
0.924	0.869	0.983	14.0	46
0.919	0.887	0.952	9.6	Total

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