Figures & data
Figure 1 Endogenous and exogenous pathways of acidification and functional consequences in the stratum corneum. Acidification in the SC is the result of several mechanisms. Specific functions of the SC are dependent on this process to maintain the epidermal permeability barrier.
Figure 2 The downstream effects of the phopholipid to free fatty acid pathway in the stratum corneum interstices. Lamellar bodies deliver both phospholipid and sPLA2 to the SC. This pathway, mediated by sPLA2, plays a functional, as well as structural role, in the maintenance of the barrier.
Table 1 Localization and function of sPLA2 subtypes in the epidermis.