Figures & data
Figure 1. LINE-1 methylation in normal human fibroblasts (WI-38) and colon epithelial cells (FHC) exposed to normal (n = 12) or supra-physiological (n = 18) folate concentrations over 3 passages. Columns and bars show the mean ± standard error. *p < 0.05.
Figure 2. LINE-1 methylation in normal human fibroblasts (WI-38) cultured in RPMI 1640 supplemented with 0, 0.01, 0.1, 1 or 10 µM folic acid or EMEM over 3 passages (n = 3). Columns and bars show the mean ± standard error. *p < 0.05 for comparisons with 0.01 µM folic acid.
Figure 3. CpG island methylation of ESR1 and p16 in human fibroblasts (WI-38) and colon epithelial cells (FHC) exposed to normal (n = 12) or supra-physiological (n = 18) folate concentrations for 3 passages. Columns and bars show the mean ± standard error. *p < 0.01.
Figure 4. Intracellular SAM:SAH ratio in human fibroblasts (WI-38) and colon epithelial cells (FHC) exposed to normal (n = 12) or supra-physiological (n = 18) folate concentrations over 3 passages. Columns and bars show the mean ± standard error. *p < 0.001.
