Figures & data
Figure 1. Ski is expressed in young cortical neurons. Distributions of bromodeoxyuridine (BrdU) birth date-labeled cells in E17.5 neocortex after BrdU injection at E12.5 (A) and at E14.5 (B) are shown. E12.5-born neurons located in layer VI are only weakly positive for Ski (arrows in A and in higher magnifications). E14.5-born neurons located in superficial layers of the cortical plate (CP) are strongly positive for Ski (arrows in B and in higher magnifications). Scale bars represent 20 µm.
Figure 2. A mechanistic model for the repressor function of Ski. Ski is required to assemble a functional Sin3 (A) and NuRD (C) repressor complex at target sequences. In the absence of Ski, recruitment of HDAC to the Sin3 (B) and NuRD (D) complex is impaired resulting in misregulation of cell proliferation/differentiation (A,B) and cell specification (C,D), respectively.
