Figures & data
Table 1. Maternal Demographics by CES-D and History of Depression: NEST
Table 2. Multivariate Model – Depressed Mood and birth weight, overall and stratified by race/ethnicity and infant sex
Figure 1. Methylation at MEG3 for infants of women with severe and no depressed mood. shows the median and IQR of infant methylation levels at the MEG3 DMR. Overall, MEG3 DMR methylation levels are higher in infants of women with severe compared with no depressed mood, p = 0.02. This difference exists in female infants (75.6% vs. 72.0%, p < 0.01) and Blacks (74.8% vs. 72.5%, p = 0.08).
Figure 2. Infant methylation at IGF2 by LBW. shows the median and IQR for infant methylation levels at the IGF2 DMR. Overall, mean methylation at IGF2 DMR is lower for LBW compared with normal weight infants, 49.5% and 51.1%, p = 0.06. This difference persists among female infants (49.2% vs. 51.5%, p = 0.03) and Blacks (47.9% vs. 49.9%, p = 0.08).
Figure 3. Infant methylation at PLAGL1 and PEG10 for high birth weight infants. shows the median and IQR of infant methylation levels at the PEG10 and PLAGL1 DMRs for high and normal birth weight infants. High birth weight is associated with increased methylation at the PLAGL1 DMR, Wilcoxon rank sum p = 0.02, and at the PEG10 DMR, Wilcoxon rank sum p = 0.06.
