Figures & data
Figure 1. Summary of HDACs and HATs described in the text.
Figure 2. Speculative models of HDAC activity during triplet repeat expansions. (A) Gatekeeper hypothesis. The nucleosome structure at triplet repeats (arrows) and changes to histone tail acetylation are shown. Expansion promoting proteins are theorized to have improved access to the TNR DNA upon histone deacetylation. (B) Caretaker hypothesis. Stabilization of expansion promoting proteins (such as Sae2) by deacetylation allows these proteins more opportunity to travel to the trinucleotide repeat and catalyze the expansion.
