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Epigenetics Volume 7, 2012 - Issue 10
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Review

Histone phosphorylation

A chromatin modification involved in diverse nuclear events

Dorine Rossetto Laval University Cancer Research Center, Hôtel-Dieu de Québec (CHUQ); Quebec City, QC Canada
,
Nikita Avvakumov Laval University Cancer Research Center, Hôtel-Dieu de Québec (CHUQ); Quebec City, QC Canada
&
Jacques Côté Laval University Cancer Research Center, Hôtel-Dieu de Québec (CHUQ); Quebec City, QC CanadaCorrespondence[email protected]
Pages 1098-1108 | Published online: 04 Sep 2012

Figures & data

Figure 1. Examples of crosstalk between phosphorylation and other histone post-translational modifications. The histone H3 N-terminal tail is presented as example of a platform harboring multiples PTMs showing crosstalks in cis with different sites of phosphorylation. Recent in vitro findings using time-resolved NMR spectroscopy suggest a slightly modified picture in which H3S10ph acts as master switch for subsequent intramolecular modifications, and inhibits T6 and T11 phosphorylation while the reverse does not apply.Citation139 This study also questioned the role of T11ph in the stimulation of K14ac.

Figure 1. Examples of crosstalk between phosphorylation and other histone post-translational modifications. The histone H3 N-terminal tail is presented as example of a platform harboring multiples PTMs showing crosstalks in cis with different sites of phosphorylation. Recent in vitro findings using time-resolved NMR spectroscopy suggest a slightly modified picture in which H3S10ph acts as master switch for subsequent intramolecular modifications, and inhibits T6 and T11 phosphorylation while the reverse does not apply.Citation139 This study also questioned the role of T11ph in the stimulation of K14ac.

Table 1. Sites of histone phosphorylation, their known kinases and functions

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