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Research Paper

Global and gene-specific promoter methylation analysis in primary hyperparathyroidism

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Pages 646-655 | Received 05 Feb 2013, Accepted 24 Apr 2013, Published online: 13 Jun 2013

Figures & data

Table 1. Results from gene specific and global methylation analyses in the 72 parathyroid tumors

Figure 1. Individual value plot showing gene-specific MetI for individual samples. For each gene, MetI in three normal references (N) and 72 parathyroid tumors (T) are shown next to each other.

Figure 1. Individual value plot showing gene-specific MetI for individual samples. For each gene, MetI in three normal references (N) and 72 parathyroid tumors (T) are shown next to each other.

Figure 2. Gene-specific MetI in the parathyroid tumor subgroups studied. (A) Parathyroid adenomas (n = 66). (B) Atypical parathyroid adenomas (n = 3). (C) Parathyroid carcinomas (n = 3). (D) MEN1 and CDC73 mutated adenomas. For each gene, MetI in normal references (N) and parathyroid tumors are shown next to each other. T refers to tumor samples, N to normal samples, M to MEN1 mutated and H to CDC73 mutated tumors.

Figure 2. Gene-specific MetI in the parathyroid tumor subgroups studied. (A) Parathyroid adenomas (n = 66). (B) Atypical parathyroid adenomas (n = 3). (C) Parathyroid carcinomas (n = 3). (D) MEN1 and CDC73 mutated adenomas. For each gene, MetI in normal references (N) and parathyroid tumors are shown next to each other. T refers to tumor samples, N to normal samples, M to MEN1 mutated and H to CDC73 mutated tumors.

Figure 3. Global methylation of LINE-1 in parathyroid tumors and normal references. The MetI is shown for each sample in the different tumor subgroups. (n) refers to total number of cases.

Figure 3. Global methylation of LINE-1 in parathyroid tumors and normal references. The MetI is shown for each sample in the different tumor subgroups. (n) refers to total number of cases.

Table 2. MetI and mRNA expression in 52 adenomas for genes showing promoter hypermethylation

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