SWItching on the transcriptional circuitry in melanoma

Figures & data

Figure 1 (A) List of Mammalian SWI/SNF components including gene names and other commonly used designations. (B) Diverse SWI/SNF complexes containing either BRG1 or BRM and associated factors exist in mammalian cells. BRG1 and BRM are mutually exclusive. (C) Schematic comparison of BRG1 and BRM structure. The two ATPases are 70% identical, containing conserved as well as unique sequences. Stars represent lysine residues in BRM that can be post-translationally modified by acetylation.

Figure 2 Potential contribution of distinct SWI/SNF complexes containing either BRG1 or BRM in the regulation of different classes of MITF target genes.9

Keenen B, Qi H, Saladi SV, Yeung M, de la Serna IL. Heterogeneous SWI/SNF chromatin remodeling complexes promote expression of microphthalmia-associated transcription factor target genes in melanoma. Oncogene 29:81 - 92

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