Figures & data
Figure 1 The various chromatin states of CpG islands. CpG islands have the capacity to adopt multiple chromatin states each with varying propensities for gene activation or repression (see main text for a description of these). Central to the capability of CpG islands to adopt and transition between these states is the default permissive state (A), partly imposed by the ZF-CxxC proteins KDM2A and CFP1. Nucleosomes within CpG islands are depicted in green and nucleosomes outside of CpG islands are grey. Straight arrows represent pathways of transition between individual CpG island states. Circular arrow represents a cell cycle involving initiation of DNA replication from CpG island ORIs.
