Figures & data
Figure 1. Key components of the insulin-signaling pathway in Drosophila. The pathway regulates growth by suppressing the activity of the transcription factor FOXO. When nutrition and IIS is low FOXO is activated and targets the expression of growth inhibitors. For a more detailed version of the IIS in Drosophila see www.reactome.org.Citation18
Figure 2. Organ-autonomously altering the expression of IIS genes affects an organ’s nutritional variability and its scaling relationship with body size. (A) Increasing FOXO expression in the wing using an imaginal-disc specific driver (NP6333 > FOXO.wt) makes the wing significantly more hyperallometric to body size, by decreasing wing size in smaller individuals (data from Figure 5 Tang et al.,Citation26 common slope test, p < 0.01) (B) Increasing Inr expression (NP6333 > Inr) also makes the wing significantly more hyperallometric but by increasing wing size in larger individuals (common slope test, p < 0.01). Flies were reared and statistical analysis conducted as described in Tang et al.Citation26 Flies for Inr overexpression were from the Bloomington Stock Center (stock no. 8262). All lines are standardized major axes.
