Figures & data
Figure 1. Speculative model of the role of Sudestada1 (Sud 1) in cell physiology and organ growth. Sud1 mediates the hydroxylation of RPS23, thereby affecting ribosomal function (translation fidelity). Sud1 inhibition might provoke defects in stop-codon recognition that in turn leads to protein misfolding, accumulation of protein aggregates and consequent UPR activation. UPR in turn induces autophagy and apoptosis, thereby affecting cell and tissue growth.
![Figure 1. Speculative model of the role of Sudestada1 (Sud 1) in cell physiology and organ growth. Sud1 mediates the hydroxylation of RPS23, thereby affecting ribosomal function (translation fidelity). Sud1 inhibition might provoke defects in stop-codon recognition that in turn leads to protein misfolding, accumulation of protein aggregates and consequent UPR activation. UPR in turn induces autophagy and apoptosis, thereby affecting cell and tissue growth.](/cms/asset/21b734b1-773c-49f1-ab44-a000d23b9c61/kfly_a_983841_f0001_b.gif)