Impact of rotavirus vaccination in regions with low and moderate vaccine uptake in Germany

Figures & data

Figure 1. Annual incidence of reported RV hospitalization per 100,000 by age group and region (eastern federal states, EFS vs. western federal states, WFS), Germany, 2001/02 through 2010/11 (note different scales for (A and B) vs. (C and D) vs. (E and F)

Table 1. Rotavirus vaccination coverage (in %) with 95% confidence intervals by geographic region in Germany (EFS and WFS) and year of birth

Region	2006	2007	2008	2009	2010
EFS	3.8 (0.7–6.8)	7.2 (2.7–11.8)	40 (31–48)	59 (51–67)	56 (45–68)
WFS	2.5 (1.4–3.6)	4.8 (3.3–6.3)	15 (12–17)	22 (20–25)	28 (24–32)

Table 2. Number and incidence (per 100,000 population) of reported RV-related hospitalizations by age-group in the pre-vaccination period (2004–2006) and changes (in %) in the post-vaccine introduction seasons when compared with the pre-vaccination period in the (A) EFS and (B) WFS of Germany

(A) Eastern Federal States (EFS, n = 5)
	Mean per season in seasons 2004–06			Season 2008/09			Season 2009/10			Season 2010/11
Age group	Number	Incidence		Incidence	Change, %*		Incidence	Change, %*		Incidence	Change, %*
< 6 mo	880	1798		1410	-22^#		1435	-20^#		1076	-40^#
6–11 mo	1264	2585		1613	-38^#		1220	-53^#		1114	-57^#
12–17 mo	1020	2076		1753	-16^#		1189	-43^#		1226	-41^#
18–23 mo	749	1525		1379	-10		975	-36^#		1189	-22^#
24–29 mo	437	897		844	-6		759	-15		836	-7
30–35 mo	296	607		600	-1		553	-9		733	21
36–41 mo	176	359		384	7		306	-15		578	61^#
42–47 mo	129	263		289	10		273	4		473	80^#
48–53 mo	108	216		258	19		184	-15		297	37^#
54–59 mo	82	164		175	7		186	14		270	65^#
5–9 y	266	58		67	15		58	0.2		100	72^#
10–64 y	425	4.4		8.1	84^#		10.1	130^#		10.9	148^#
65+ yrs	582	21		49	132^#		58	174^#		75	257^#
(B) Western Federal States (WFS, n = 11)
	Mean per season in seasons 2004–06			Season 2008/09			Season 2009/10			Season 2010/11
Age group	Number	Incidence		Incidence	Change, %*		Incidence	Change, %*		Incidence	Change, %*
< 6 mo	2397	809		744	-8^#		702	-13^#		587	-27^#
6–11 mo	3491	1180		1008	-15^#		831	-30^#		851	-28^#
12–17 mo	3077	1016		1085	7		938	-8^#		879	-14^#
18–23 mo	2171	717		766	7		781	9^#		734	2
24–29 mo	1324	431		484	12		491	14^#		492	14^#
30–35 mo	902	294		365	24^#		338	15^#		403	7^#
36–41 mo	620	197		245	24^#		262	33^#		288	46^#
42–47 mo	470	149		188	26^#		201	35^#		230	54^#
48–53 mo	362	111		137	23^#		145	31^#		165	48^#
54–59 mo	292	90		125	40^#		122	36^#		140	56^#
5–9 y	904	26		37	42^#		40	54^#		43	67^#
10–64 y	736	1.5		2.9	93^#		3.5	133^#		2.7	80^#
65+ yrs	1133	8.8		20.2	130^#		20.3	131^#		15.0	71^#

* Compared with the mean annual incidence of the reference period (seasons 2004–06) ^#significant change; yrs, years

Table 3. Mean annual incidence of nosocomial RV-infections (per 100,000 population) in the pre- and post-vaccine introduction period by age-group, Germany, 2004–06 compared with 2008–11

	EFS, n = 5				WFS, n = 11
Age group	Mean Incidence per season 2004–06	Mean Incidence per season 2008–11	Change, %		Mean Incidence per season 2004–06	Mean Incidence per season 2008–11	Change, %
< 6 mo	214	225	5		156	117	-25^#
6–11 mo	148	94	-36^#		108	66	-38^#
12–17 mo	109	79	-28		59	57	-4
18–23 mo	54	36	-33		35.8	36.3	1
2–4 y	29	23	-20		10.0	9.5	-5
5–9 y	2.7	2.3	-15		2.2	2.5	11
10–64 y	0.6	1.5	158^#		0.3	0.5	73^#
65+ yrs	5.6	14.8	163^#		3.1	6.3	103^#

^# significant change (p-value < 0.05); yrs, years

Table 4. Estimated incidence rate ratio (IRR) by age group when vaccinating 50% of the eligible unvaccinated population

	IRR*	95% CI
Age group
< 6 mo	0.73	0.45–1.18
6–11 mo	0.58	0.48- 0.70
11–17 mo	0.62	0.51–0.77
18–23 mo	0.78	0.63- 0.97
24–29 mo	0.85	0.57 - 1.26
30–35 mo	1.18	0.79- 1.78

* Adjusted for different incidences in EFS and WFS, and age groups. IRR, incidence rate ratio