Drug allergy

Figures & data

Figure 1. MHC presentation of drug-haptenated peptide to the T cell receptor.

Figure 2. Activation of T cell &/or Dendritic cell by non-covalent binding of drug to T cell receptor or MHC.

Table 1. Common drug allergies and desensitizations

Drugs	Common allergic reactions	Standardized desensitization	References
Penicillins	Anaphylaxis, urticaria, angioedema	Yes	72,95
Other β-lactams	Urticaria, angioedema Anaphylaxis	Yes	75
Platins	Anaphylaxis, anaphylactoid	Yes	75
Monoclonals	Anaphylaxis	Yes	96
Taxanes	Anaphylaxis, anaphylactoid	Yes	46
Muscle relaxants	Anaphylaxis	No
ASA	Asthma, urticaria, angioedema	Yes	57,80
Angiotensin-inhibitors	Angioedema	No
Sulphamethoxazole	Maculopapular rashes	Yes	94,97
Anti-convulsants	Drug-induced Hypersensitivity	No
Multiple drugs, e.g sulphonamides, abacavir	Stevens-Johnson, Toxic epidermal necrolyis	No
Multiple drugs, e.g., flucloxacillin	Drug-induced liver disease	No

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