Figures & data
Figure 1. Signaling pathways of innate immunity involved in DNA-sensing. DNA can be recognized by different sensors, including TLR9, DAI, AIM2, IFI16 and LRRFIP1. As result of downstream signaling, NF-κB and IRF transcription factors become activated to promote the expression of different proinflammatory cytokines, and IFN-α/β.
![Figure 1. Signaling pathways of innate immunity involved in DNA-sensing. DNA can be recognized by different sensors, including TLR9, DAI, AIM2, IFI16 and LRRFIP1. As result of downstream signaling, NF-κB and IRF transcription factors become activated to promote the expression of different proinflammatory cytokines, and IFN-α/β.](/cms/asset/3486ffc3-2859-4083-af7f-d2a1b353ee37/khvi_a_10922345_f0001.gif)
Table 1. DNA vaccination clinical trials targeting cancer
Figure 2. Genetic adjuvants for enhancing the potency of DNA vaccines against cancer: Overexpression vs. silencing. Genetic (DNA-encoded) adjuvants used for DNA vaccines can be designed to either overexpress immune-stimulatory molecules (left side of the scale), or downregulate the gene expression of inhibitory molecules (right side of the scale).
![Figure 2. Genetic adjuvants for enhancing the potency of DNA vaccines against cancer: Overexpression vs. silencing. Genetic (DNA-encoded) adjuvants used for DNA vaccines can be designed to either overexpress immune-stimulatory molecules (left side of the scale), or downregulate the gene expression of inhibitory molecules (right side of the scale).](/cms/asset/422a6aab-0e00-4de7-b428-0ed2a7718a1e/khvi_a_10922345_f0002.gif)