Assessing the burden of HPV-related cancers in Appalachia

Figures & data

Table 1. Incidence of HPV-related cancers among females, 1996–2008 (all races)

	All HPV-Related^a		Cervix		Vulva		Anus		Vagina		Oral Cavity/Pharynx
	Cases	IR (95% CI)	Cases	IR (95% CI)	Cases	IR (95% CI)	Cases	IR (95% CI)	Cases	IR (95% CI)	Cases	IR (95% CI)
US (SEER 9)	35,243	18.8 (18.6-19.0)	14,093	7.7 (7.6-7.8)	4,547	2.4 (2.3-2.4)	2,982	1.6 (1.5-1.6)	1,334	0.7 (0.7-0.7)	12,287	6.5 (6.4-6.6)
Kentucky	6,663	22.8 (22.2-23.3)	3,002	10.7 (10.3-11.0)	896	3.0 (2.8-3.2)	588	2.0 (1.8-2.1)	257	0.8 (0.7-0.9)	1,920	6.3 (6.1-6.6)
Appalachia	2,031	24.6 (23.5-25.7)	982	12.4 (11.6-13.2)	308	3.6 (3.2-4.0)	157	1.8 (1.6-2.1)	73	0.9 (0.7-1.1)	511	5.9 (5.4-6.4)
Non-Appalachia	4,632	22.0 (21.4-22.7)	2,020	10.0 (9.5-10.4)	588	2.7 (2.5-2.9)	431	2.0 (1.8-2.2)	184	0.8 (0.7-1.0)	1,409	6.5 (6.2-6.8)
Ohio	15,813	19.0 (18.7-19.3)	6,646	8.4 (8.2-8.7)	2,204	2.5 (2.4-2.6)	1,351	1.6 (1.5-1.7)	607	0.7 (0.6-0.7)	5,005	5.8 (5.6-5.9)
Appalachia	2,307	21.9 (21.0-22.8)	1,080	10.9 (10.2-11.6)	332	2.9 (2.6-3.3)	205	1.9 (1.6-2.2)	90	0.8 (0.6-1.0)	600	5.4 (5.0-5.8)
Non-Appalachia	13,506	18.6 (18.3-18.9)	5,566	8.1 (7.9-8.3)	1,872	2.4 (2.3-2.5)	1,146	1.5 (1.5-1.6)	517	0.7 (0.6-0.7)	4,405	5.8 (5.7-6.0)
West Virginia^b	3,200	22.8 (22.0-23.6)	1,429	11.1 (10.5-11.7)	442	2.9 (2.6-3.2)	308	2.1 (1.9-2.3)	132	0.9 (0.7-1.0)	889	5.9 (5.5-6.3)

HPV, human papillomavirus; IR, incidence rate; CI, confidence interval; SEER, Surveillance, Epidemiology and End Results. All rates are expressed per 100,000 population and are age-adjusted to the 2000 U.S. standard population. ^aIncludes cervical, vulvar, anal, vaginal and oral cavity/pharyngeal cancers. ^bThe entire state of West Virginia is in the Appalachian region.

Figure 1. Incidence of HPV-related cancers by county among females from Ohio, West Virginia and Kentucky (1996–2008; all races). HPV-related cancers include cervical, vulvar, anal, vaginal and oral cavity/pharyngeal cancers. All rates are age-adjusted to the 2000 U.S. standard population.

Table 2. Incidence of HPV-related cancers among males, 1996–2008 (all races)

	All HPV-Related^a		Penis		Anus		Oral Cavity / Pharynx
	Cases	IR (95% CI)	Cases	IR (95% CI)	Cases	IR (95% CI)	Cases	IR (95% CI)
US (SEER 9)	28,946	18.3 (18.1–18.6)	1,164	0.8 (0.8–0.9)	2,148	1.3 (1.3–1.4)	25,634	16.2 (16.0–16.4)
Kentucky	5,436	21.7 (21.2–22.3)	305	1.3 (1.1–1.4)	296	1.2 (1.1–1.3)	4,835	19.3 (18.7–19.8)
Appalachia	1,563	21.3 (20.2–22.4)	124	1.7 (1.4–2.0)	82	1.1 (0.9–1.4)	1,357	18.4 (17.4–19.4)
Non-Appalachia	3,873	21.9 (21.2–22.7)	181	1.1 (1.0–1.3)	214	1.2 (1.0–1.4)	3,478	19.6 (19.0–20.3)
Ohio	11,638	16.5 (16.2–16.8)	533	0.8 (0.7–0.9)	766	1.1 (1.0–1.2)	10,339	14.6 (14.3–14.9)
Appalachia	1,663	17.6 (16.8–18.5)	100	1.1 (0.9–1.3)	100	1.1 (0.9–1.3)	1,463	15.5 (14.7–16.3)
Non-Appalachia	9,975	16.3 (16.0–16.6)	433	0.7 (0.7–0.8)	666	1.1 (1.0–1.2)	8,876	14.5 (14.2–14.8)
West Virginia^b	2,418	19.2 (18.4–19.9)	144	1.2 (1.0–1.4)	148	1.2 (1.0–1.4)	2,126	16.8 (16.1–17.5)

HPV, human papillomavirus; IR, incidence rate; CI, confidence interval; SEER, Surveillance, Epidemiology and End Results. All rates are expressed per 100,000 population and are age-adjusted to the 2000 U.S. standard population. ^aIncludes penile, anal and oral cavity/pharyngeal cancers. ^bThe entire state of West Virginia is in the Appalachian region.

Figure 2. Incidence of HPV-related cancers by county among males from Ohio, West Virginia and Kentucky (1996–2008; all races). HPV-related cancers include penile, anal and oral cavity/pharyngeal cancers. All rates are age-adjusted to the 2000 U.S. standard population.