Epidemiology of HBV S-gene mutants in the Liguria Region, Italy

Figures & data

Table 1. Patient characteristics

	n = 256
Gender, male/female	185/71
Age (yr), min-max (median)	12–88 (53)
Race, n(%) African	4 (1.6)
Asian	16 (6.2)
Caucasian	236 (92.2)
Alanine Aminotransferase levels (UI/mL), min-max (median)	12–3,486 (44.5)
HBsAg positive n(%)	253 (98.8)
HBV DNA levels (UI/mL), min-max (media)	3x10^1 - 6,8x10^8 (5.2x10^5)
Genotype distribution, n(%)
A	40 (15.6)
B	6 (2.3)
C	14 (5.5)
D	189 (73.8)
E	2 (0.8)
F	4 (1.6)
G	1 (0.4)

Table 2. Demographic and clinic characteristics, treatment, serology and surface gene mutations in the 8 cases with 145R mutation

Case	Age(yr)/sex	Race	Genotype	HBV DNA level (UI/mL)	ALT (UI/mL)/bilirubin (mg/dL)*	Treatment	HBsAg detection, by immunoassay kits					HBsAg mutations
							EIAgen	AxSYM	Architect	Vitros	Monolisa Ultra
1	88/Male	Caucasian	D	1.7x10^7	121/0.66	No	negative	positive	positive	negative	negative	G145R, T126I, T131A, C139Y, E/D144G
2	56/Male	Caucasian	A	2.4x10^4	47/1.52	Yes	negative	positive	positive	negative	negative	G145R, T126I, M133L
3	38/Female	Caucasian	D	1.6x10^6	562/4.8	No	positive	positive	positive	positive	positive	G145R
4	60/Female	Caucasian	D	4.4x10^3	11/0.27	No	positive	positive	positive	positive	positive	G145R
5	74/Male	Caucasian	D	8.2x10^4	84/0.65	No	positive	positive	positive	positive	positive	G145R
6	51/Male	Caucasian	D	4.2x10^3	324/0.48	No	negative	positive	positive	negative	negative	G145R, P120Q, T126I
7	55/Male	African	D	6.7x10^6	15/0.4	No	positive	positive	positive	positive	positive	G145A
8	40/Male	Caucasian	C	3.0x10^1	33/1.41	Yes	positive	positive	positive	positive	positive	G145R

*Alanine Aminotransferase level, reference range 0–40 U/L; total bilirubin reference range 0.4–1.2 mg/dL.