Figures & data
Figure 1. Virus-like particles constitute potential platforms able to carry full-length HCV E1-E2 envelope proteins in an appropriate conformation. (A) Murine leukemia virus (MLV) particles formed by the production of the retroviral Gag protein alone can incorporate HCV E1-E2 proteins. (B) Hepatitis B virus (HBV) surface protein self-assembles into subviral, noninfectious particles, which can be used as an effective hepatitis B vaccine. Similar particles can be obtained with chimeric proteins formed by the fusion of the HBV S protein with the HCV E1 and/or E2 proteins. Both pseudotyped MLV-like particles and chimeric HBV-HCV subviral envelope particles have been shown to induce antibodies cross-neutralizing various HCV genotypes.
