Peptide intra-tumor injection for cancer immunotherapy

Figures & data

Figure 1. A proposed mechanistic model of peptide intra-tumor injection for improved antigen-specific cancer immunotherapy against solid tumors. The upper row shows a general view of a tumor, and the lower row shows greater detail. The peptide injected into the tumor is shown in red in this schematic diagram. CTL, cytotoxic T lymphocyte. APC, antigen-presenting cell. TCR, T-cell receptor. MHC, major histocompatibility complex. Adapted from Nobuoka et al.⁶

Nobuoka D, Yoshikawa T, Takahashi M, Iwama T, Horie K, Shimomura M, et al. Intratumoral peptide injection enhances tumor cell antigenicity recognized by cytotoxic T lymphocytes: a potential option for improvement in antigen-specific cancer immunotherapy. Cancer Immunol Immunother 2012; In press http://dx.doi.org/10.1007/s00262-012-1366-6; PMID: 23143746

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