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Human Vaccines & Immunotherapeutics Volume 9, 2013 - Issue 7: Special Focus: VR6 Conference
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Commentary

Delivery of immunogens to mucosal immune system using an oral inactivated cholera vaccine

A new approach for development of oral vaccines

Ali Azizi Department of Pathology and Laboratory Medicine; University of Ottawa; Ottawa, ON CanadaCorrespondence[email protected]
,
Haitham Ghunaim Children's Hospital of Eastern Ontario; Research Institute; Ottawa, ON Canada
,
Danylo Sirskyj Department of Pathology and Laboratory Medicine; University of Ottawa; Ottawa, ON Canada; Children's Hospital of Eastern Ontario; Research Institute; Ottawa, ON Canada
,
Firouzeh Fallahi Canadian Food Inspection Agency; Toronto, ON Canada
,
Hoang Thanh Le Department of Research; Sudbury Regional Hospital; Sudbury, ON Canada
&
Ashok Kumar Department of Pathology and Laboratory Medicine; University of Ottawa; Ottawa, ON Canada; Children's Hospital of Eastern Ontario; Research Institute; Ottawa, ON Canada; Department of Biochemistry; Microbiology and Immunology; University of Ottawa; Ottawa, ON Canada
Pages 1445-1448 | Received 19 Feb 2013, Accepted 05 Mar 2013, Published online: 06 Mar 2013

Figures & data

Figure 1. HIV-1 specific serum IgG (A) and HIV-1 specific fecal IgA (B) antibody titers following oral immunization. Mice (n = 6) were immunized orally on days 0, 14 and 28 with chitosan nanospheres loaded with HIV-1 Gp120 proteins MN, CM, LAN and Dukoral. Sera and fecal samples were collected after each vaccination and HIV-1 specific serum IgG (A) and HIV-1 specific fecal IgA (B) antibodies were measured by ELISA. Results are shown as the mean O.D 450 nm ± SEM. The arrows indicate the day of vaccine administration.

Figure 1. HIV-1 specific serum IgG (A) and HIV-1 specific fecal IgA (B) antibody titers following oral immunization. Mice (n = 6) were immunized orally on days 0, 14 and 28 with chitosan nanospheres loaded with HIV-1 Gp120 proteins MN, CM, LAN and Dukoral. Sera and fecal samples were collected after each vaccination and HIV-1 specific serum IgG (A) and HIV-1 specific fecal IgA (B) antibodies were measured by ELISA. Results are shown as the mean O.D 450 nm ± SEM. The arrows indicate the day of vaccine administration.

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