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Product History

Pollinex Quattro: An innovative four injections immunotherapy In allergic rhinitis

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Pages 1523-1531 | Received 31 Jan 2013, Accepted 10 Apr 2013, Published online: 12 Apr 2013

Figures & data

Figure 1. Mechanism of conventional (left) and ultra short course specific immunotherapy (right).

Figure 1. Mechanism of conventional (left) and ultra short course specific immunotherapy (right).

Table 1. Thirteen grass product

Figure 2. Basophil histamin-release in patients treated with four injections of Pollinex Quattro (left) or placebo (right) before and after treatment.Citation19

Figure 2. Basophil histamin-release in patients treated with four injections of Pollinex Quattro (left) or placebo (right) before and after treatment.Citation19

Figure 3. Leukotriene levels as a surrogate parameter of inhibiting antibodies before and after immunotherapy.Citation20

Figure 3. Leukotriene levels as a surrogate parameter of inhibiting antibodies before and after immunotherapy.Citation20

Table 2. Overview of phase 3 clinical studies and post-marketing trials with Pollinex Quattro: study design and key results

Figure 4. Combined Symptom/medication Score in the randomized, placebo-controlled phase 3 study in patients with tree pollen allergy (n = 58).Citation18

Figure 4. Combined Symptom/medication Score in the randomized, placebo-controlled phase 3 study in patients with tree pollen allergy (n = 58).Citation18

Figure 5. Proportion of well subjects; i. e. CSMS ≤ 2 during the peak pollen season (a; n = 973) and median number of well days; i.e., patients with a score ≤ 2 and no anti-allergic medication (b; n = 990) in the randomized, placebo-controlled phase 3 study.Citation26

Figure 5. Proportion of well subjects; i. e. CSMS ≤ 2 during the peak pollen season (a; n = 973) and median number of well days; i.e., patients with a score ≤ 2 and no anti-allergic medication (b; n = 990) in the randomized, placebo-controlled phase 3 study.Citation26

Figure 6. Use of symptomatic medication during therapy in 324 patient completing 3 y of immunization.Citation28

Figure 6. Use of symptomatic medication during therapy in 324 patient completing 3 y of immunization.Citation28

Table 3. Summary of local adverse events in clinical trials during the treatment period

Figure 7. Therapy tolerability (a) and acceptance (b) in adults (n = 2,692) and children/adolescents (n = 422).Citation28

Figure 7. Therapy tolerability (a) and acceptance (b) in adults (n = 2,692) and children/adolescents (n = 422).Citation28