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Human Vaccines & Immunotherapeutics Volume 11, 2015 - Issue 1
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Research Paper

Hepatitis B vaccination

Are escape mutant viruses a matter of concern?

Luisa Romanò Dipartimento di Scienze Biomediche per la Salute; Università degli Studi di Milano; Milano, Italy
,
Sara Paladini Dipartimento di Scienze Biomediche per la Salute; Università degli Studi di Milano; Milano, Italy
,
Cristina Galli Dipartimento di Scienze Biomediche per la Salute; Università degli Studi di Milano; Milano, Italy
,
Giovanni Raimondo Dipartimento di Medicina Clinica e Sperimentale; Università degli Studi di Messina; Messina, Italy
,
Teresa Pollicino Dipartimento di Scienze Pediatriche, Ginecologiche; Microbiologiche e Biomediche, Università degli Studi di Messina; Messina, Italy
&
Alessandro R Zanetti Dipartimento di Scienze Biomediche per la Salute; Università degli Studi di Milano; Milano, ItalyCorrespondence[email protected]
Pages 53-57 | Received 03 Jul 2014, Accepted 10 Jul 2014, Published online: 01 Nov 2014

Figures & data

Figure 1. Schematic representation of the overlap between the HBV polymerase and envelope open reading frames. The numbers indicate amino acid (aa) sites. Numbering is according to genotype D. The a determinant of HBsAg that is located between aa 124 and 149, and which includes the major antibody neutralization domain of HBV, is indicated.

Figure 1. Schematic representation of the overlap between the HBV polymerase and envelope open reading frames. The numbers indicate amino acid (aa) sites. Numbering is according to genotype D. The a determinant of HBsAg that is located between aa 124 and 149, and which includes the major antibody neutralization domain of HBV, is indicated.

Table 1. Major drug-resistant mutations in the HBV reverse-transcriptase (rt) resulting in structural changes in the HBsAg protein

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