Potential effect of PCV13 introduction on Emergency Department accesses for lower respiratory tract infections in elderly and at risk adults

Figures & data

Table 1. Study population and risk factors according age groups

	Age group
	18–44 y	45–64 y	65–84 y	> 84 y	Total
N.	152 148	147 885	119 328	18 260	437 621
Gender, male (N., %)	75 382 (49.5)	71 198 (48,1)	51 294 (43)	5448 (29.8)	204 298 (46.7)
Chronic respiratory disease (N., %)	6286 (4.1)	5634 (3.8)	9099 (7.6)	2035 (11.1)	23 054 (5.3)
Chronic cardiovascular disease (N., %)	595 (0,4)	6371 (4.3)	24,502 (20.5)	6333 (34.7)	34 802 (8)
Diabetes Mellitus and other Metab. Dis. (N., %)	6975 (4.6)	26 572 (18)	42 715 (35.8)	5697 (31.2)	81 960 (18.7)
Chronic Kidney Disease (N., %)	192 (0.1)	711 (0.5)	2640 (2.2)	1238 (6.8)	4781 (1.1)
Cancer (N., %)	1993 (1.3)	9356 (6.3)	19 147 (16.1)	3217 (17.6)	33 713 (7.7)
Immunodeficiency (N., %)	208 (0.1)	356 (0.2)			564 (0.1)
Transplantation (N., %)	129 (0.1)	294 (0.2)	206 (0.2)	22 (0.1)	652 (0.2)
Pregnancy (II and III trim) (N., %)	3015 (2)				3015 (0.7)

Table 2. Hospital access for LRTI during the 3 seasons according age groups

	Hospital access for LRTI (N./1000 y, 95% C.I.) during the 3 seasons
	2010/2011	2011/12	2012/13
Age group
15–44 y	1.9 (1.7–2.1)	1.4 (1.2–1.6)	1.4 (1.4–1.6)
44–64 y	1.8 (1.5–2)	1.6 (1.4–1.8)	2.1 (1.9–2.3)
65–84 y	5.2 (4.8–5.6)	5.6 (5.2–6)	5.7 (5.3–6.1)
> 84 y	12.8 (11.2–14.5)	15.1 (13.3–16.9)	16.3 (14.4–18.1)

Figure 1. Accesses for LRTI (per 1000 y) stratified by age-group and numbers of risk factors reported for every LRTI case, 2010–2013.

Table 3. Hospital access for LRTI according age groups and risk factors

	Hospital access for LRTI (N./1000 y, 95% C.I.)
	18–44 y	45–64 y	65–84 y	> 84 y
Chronic respiratory disease	3.6 (2.8–4.5)	10.8 (9.2–12.3)	29.2 (27.2–31.2)	43.1 (38.1–18.1)
Chronic cardiovascular disease	7.8 (3.7–11.8)	5.6 (4.5–6.6)	12.1 (11.3–13)	24.5 (22.3–26.7)
Diabetes Mellitus and other Metabolic Diseases	0.6 (0.3–1)	1.1 (0.9–1.3)	2.9 (2.6–3.2)	7.4 (6.2–8.7)
Chronic kidney disease	12 (3.2–20.8)	6.5 (3.1–9.9)	12.3 (9.9–14.8)	19.3 (14.9–23.7)
Cancer	1 (0–2.4)	1.1 (0.4–1.7)	3.1 (2.3–3.9)	6.5 (3.7–9.3)
Immunodeficiency	29.5 (16.5–42.6)	23.8 (14.7–32.8)
Transplantation	5.1 (0–12.2)	5.6 (0.1–10.6)	9.6 (2–17.4)
Pregnancy (II and III trim)	0.6 (0.3–1)
No risk factors	1.4 (1.3–1.6)	1.2 (1.1–1.4)	3.5 (3.1–4)	4.5 (3.4–5.6)

Figure 2. Relative risk (RR) and 95% confidence interval (CI95%) for main risk factors stratified by age groups, 2010-2013.