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JAK-STAT Volume 2, 2013 - Issue 2
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Commentary

Mutual cytokine crosstalk between colon cancer cells and microenvironment initiates development of distant metastases

Petr Vaňhara Department of Histology and Embryology; Faculty of Medicine; Masaryk University; Brno, Czech Republic
&
Karel Souček Center of Biomolecular and Cellular Engineering; International Clinical Research Center; St. Anne’s University Hospital; Brno, Czech Republic; Department of Cytokinetics; Institute of Biophysics; Academy of Sciences of the Czech Republic; Brno, Czech RepublicCorrespondence[email protected]
Article: e23810 | Received 24 Jan 2013, Accepted 29 Jan 2013, Published online: 01 Apr 2013

Figures & data

Figure 1. Paracrine survival loop mediated by TGF-β involves induction of the Smad-dependent pathway in stromal fibroblasts, induction of IL-11 expression, and activation of the gp130STAT pathway.

Figure 1. Paracrine survival loop mediated by TGF-β involves induction of the Smad-dependent pathway in stromal fibroblasts, induction of IL-11 expression, and activation of the gp130STAT pathway.

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