Figures & data
Figure 1 Blockade of the VEGF pathway with mAbs. The specificity of the VEGF family ligands for the VEGF receptors and coreceptors are shown. The clinically-relevant mAbs targeting the anti-VEGF pathway discussed in this review are placed based on their blockade of VEGF ligand or receptor. The ligand-binding antibodies bevacizumab (bev), r84, and VEGF-Trap inhibit ligand binding to the indicated receptor. IMC-18F1 and IMC-1121B bind VEGFR1 and VEGFR2 respectively, and prevent ligand binding.
Figure 2 Current anti-angiogenic mAbs with applications in cancer therapy. hz, humanized; hu, human; ms, mouse; rt, rat; fp, fusion protein; mCRC, metastatic colorectal cancer; NSCLC, non-small cell lung cancer; mBC, metastatic breast cancer; mRCC, metastatic renal cell carcinoma.
