Various pathways leading to the acquisition of antibiotic resistance by natural transformation

Figures & data

Table 1. Minimal inhibitory concentration (MIC; µg/ml) of A. baylyi isolates obtained on transformant-selective plates as determined by the E test method

Bacterial isolate^a	AM	CAZ	CN	CTX	K	SX
A. baylyi BD413 (recipient strain)	1	1.5	0.064	1.5	0.38	16
A. baumannii 064	> 256	n.d.	> 256	n.d.	> 256	> 1024
A. baylyi (AbII)5	12	n.d.	0.5	n.d.	1	32
A. baylyi (AbII)6	1	n.d.	0.38	n.d.	> 256	48
A. baylyi (AbII)L1	32	n.d.	0.38	n.d.	0.5	24
A. baumannii 65FFC	64	> 256	n.d.	> 256	n.d.	> 1024
A. baylyi (AbI)L1	6	8	n.d.	8	n.d.	16
A. baylyi (AbI)L2	4	8	n.d.	8	n.d.	64
A. baylyi (AbI)L3	0.75	1.5	n.d.	1.5	n.d	24
P. aeruginosa SM	> 256	n.d.	16	n.d.	n.d.	> 1024
A. baylyi (Ps)1	6	n.d.	0.19	n.d.	n.d.	24
A. baylyi (Ps)L1	6	n.d.	0.5	n.d.	n.d.	24
A. baylyi (Ps)L2	6	n.d.	0.38	n.d.	n.d.	24
S. enterica Rissen 486	> 256	n.d.	n.d.	n.d.	n.d.	> 1024
A. baylyi (Sr)1	4	n.d.	n.d.	n.d.	n.d.	16
S. enterica Typhimurium 490	> 256	n.d.	n.d.	n.d.	n.d.	> 1024
A. baylyi (St)L1	6	n.d.	n.d.	n.d.	n.d.	64
A. baylyi (St)L2	6	n.d.	n.d.	n.d.	n.d.	32

See reference 25 for details.^.aA. baylyi transformants were named based on the donor from which they were acquired: AbII, A. baumannii 064; AbI, A. baumannii 65FFC; Ps, P. aeruginosa SM; Sr, S. enterica serovar Rissen 486; St, S. enterica serovar Typhimurium 490; Antibiotics: AM, ampicillin; CAZ, ceftazidime; CN, gentamicin; CTX, cefotaxime; K, kanamycin; SX, sulphamethoxazole. n.d., not determined.

Domingues S, Harms K, Fricke WF, Johnsen PJ, da Silva GJ, Nielsen KM. Natural transformation facilitates transfer of transposons, integrons and gene cassettes between bacterial species. PLoS Pathog 2012; 8:e1002837; http://dx.doi.org/10.1371/journal.ppat.1002837; PMID: 22876180

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