Figures & data
Figure 1. A schematic model describing how CBP promotes embryonic (both dorsal and ventral) forebrain precursor differentiation. S436 phosphorylation in CBP by aPKC recruits CBP to the promoter regions of neural specific genes in both embryonic dorsal and ventral forebrain precursors to enhance histone acetylation and promote precursor differentiation. TF, transcription factor; aPKC, atypical protein kinase C.
Figure 2. CBP haploinsufficiency causes decreased hippocampal neurogenesis in an age-dependent manner. CBP+/+ and CBP+/− mice at the ages of 3 mo and 7 mo were injected with BrdU and sacrificed 12 d later for quantifying total number of BrdU and NeuN positive cells in coronal sections of the hippocampal dentate gyrus. Quantitative analysis of the total number of BrdU/NeuN-positive cells in the hippocampi from CBP+/+ and CBP+/− (3-mo- and 7-mo-old). *P < 0.05 (n = 4–6 to each group). Error bars denote SEM.
