Figures & data
Figure 1 Model for two-step response to eroded telomeres. Initially, eroded telomeres are maintained in a pre-signaling state via Mps3-dependent tethering at the nuclear envelope (NE). This state promotes telomere addition by telomerase (i). Subsequently, persisting eroded telomeres relocalize to the nuclear pore complex (NPC), where homologous recombination is promoted, and they switch to a Mec1-dependent signaling state, leading to replicative senescence (ii). SPB, spindle pole body.
