695
Views
6
CrossRef citations to date
0
Altmetric
Review

Actin-related proteins localized in the nucleus

from discovery to novel roles in nuclear organization

&
Pages 38-46 | Received 26 Oct 2010, Accepted 17 Dec 2010, Published online: 01 Jan 2011

Figures & data

Figure 1 The deduced three-dimensional structure of actin-related proteins. The three-dimensional structures of isoforms of human Arp4 (Baf53b/ArpNα and Baf53a/ArpNβ) and human Arp6 were deduced with the program SWISS-Model,Citation121,Citation122 visualized with the program WebLab Viewer, and compared with that of rabbit skeletal muscle actin. The α- and β-specific regions and an Arp6-specific insertion are shown.

Figure 1 The deduced three-dimensional structure of actin-related proteins. The three-dimensional structures of isoforms of human Arp4 (Baf53b/ArpNα and Baf53a/ArpNβ) and human Arp6 were deduced with the program SWISS-Model,Citation121,Citation122 visualized with the program WebLab Viewer, and compared with that of rabbit skeletal muscle actin. The α- and β-specific regions and an Arp6-specific insertion are shown.

Figure 2 Roles of Arp6 in the local alteration of chromatin structure and the spatial organization of the nucleus. Arp6 has an essential function in chromatin remodeling through the deposition of H2A.Z by the SWR1 complex (lower chromatin). In addition, Arp6 has a role in the spatial arrangement of chromatin through its interaction with the myosin-like proteins Mlp1 and Mlp2 (upper chromatin). This function of Arp6 is independent of the SWR1 complex.

Figure 2 Roles of Arp6 in the local alteration of chromatin structure and the spatial organization of the nucleus. Arp6 has an essential function in chromatin remodeling through the deposition of H2A.Z by the SWR1 complex (lower chromatin). In addition, Arp6 has a role in the spatial arrangement of chromatin through its interaction with the myosin-like proteins Mlp1 and Mlp2 (upper chromatin). This function of Arp6 is independent of the SWR1 complex.

Table 1 Members of the actin family in budding yeast

Table 2 Chromatin-remodeling complexes including nuclear ARPs