Figures & data
Figure 1. Negative regulation of Toll-like receptor signaling. Toll-like receptor (TLR) signaling pathways are tightly regulated in multiple different ways by several endogenous regulators to prevent hyperactivation. To attenuate the signaling from TLRs, at least three levels of negative regulation have so far been reported. These range from intracellular inhibitors to extracellular decoy receptors, and membrane-bound suppressors.
Figure 2. Analysis and visualization of A20, PI3K, NOD2, TRIAD3A, SOCS1 and FADD gene expressions in a spectrum of human cancers using Oncomine database. Each individual gene was analyzed separately for differential expression between cancers vs. normal by applying indicated thresholds and compiled together for visualization. Cell color is determined by the best gene rank percentile for the analyses within the cells. Red, upregulation; Blue, downregulation.
