Figures & data
Figure 1. PolyI:C induces three antitumor effectors via different routes. Antitumor activity of polyI:C against tumor cells are assessed in mouse tumor-implant models. A unique point in this review is the third pathway where tumor-infiltrating myeloid cells are involved, effectively damages Lewis Lung carcinoma cells. This tumoricidal activity is mediated by the TICAM-1 pathway in the myeloid cells, and attributed to TNF-α. Although polyI:C is i.p. administered, it acts on tumor-infiltrating Mf and converts them to antitumor effectors.
