Figures & data
Figure 1. Implication of RORγt-expressing regulatory T cells in the pathogenesis of colon cancer. Regulatory T cells (Tregs) infiltrating the tumor environment respond to cell-extrinsic cues by upregulating retinoid-related orphan receptor γt (RORγt) and hence acquiring pro-inflammatory properties. This creates a vicious cycle of inflammation that stimulates tumor progression. Strategies for the inhibition of RORγt may interrupt this cycle and exert potent antitumor effects.
