Figures & data
Figure 1. Impact of the immune microenvironment on lung adenocarcinoma. (A) A high relative proportion of tumor-infiltrating FOXP3+ regulatory T cells (Tregs) to CD3+ T cells as well as the expression of the interleukin (IL)-7 receptor (IL-7R) by tumor cells have been associated with poor clinical outcome. In this context, IL-7 produced by tumor cells not only operates in an autocrine fashion but also can act on Tregs, which express low levels of IL-7R. (B) A low relative proportion of tumor-infiltrating FOXP3+ Tregs to CD3+ T cells as well as the expression of the IL-12 receptor (IL-12R) by tumor cells have been shown to correlate with improved clinical outcomes, de facto favoring the establishment of an antitumor local microenvironment.
