Figures & data
Figure 1. Galectin-1 contributes to the tumorigenic and metastatic potential of 4T1 breast tumors by promoting local and systemic immunosuppression. Tumor-derived galectin-1 (Gal-1) promotes the differentiation of highly suppressive FOXP3+LAT+ regulatory T cells (Tregs), which migrate from tumor-draining lymph nodes to the lung and facilitate the establishment of metastatic foci. The expression of Gal-1 by breast cancer cells favors metastatic seeding by profoundly influencing the frequency and immunosuppressive capacity of Tregs.
