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Balance is a key for happiness

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Article: e24211 | Received 27 Feb 2013, Accepted 06 Mar 2013, Published online: 01 May 2013

Figures & data

Figure 1. The balance between Type I and Type II natural killer T cells and regulatory T cells in the control of antitumor immunity. Type I natural killer T (NKT) weaken the immunosuppressive activity of their Type II counterparts, leaving regulatory T cells (Tregs) as dominant immunosuppressors (left panel). In the absence of a balance between Type I and II NKT cells, the former are unable to effectively inhibit the latter, so both Tregs and Type II NKT cells exert strong immunosuppressive effects (right panel).

Figure 1. The balance between Type I and Type II natural killer T cells and regulatory T cells in the control of antitumor immunity. Type I natural killer T (NKT) weaken the immunosuppressive activity of their Type II counterparts, leaving regulatory T cells (Tregs) as dominant immunosuppressors (left panel). In the absence of a balance between Type I and II NKT cells, the former are unable to effectively inhibit the latter, so both Tregs and Type II NKT cells exert strong immunosuppressive effects (right panel).