Figures & data
Figure 1. Dual role of IRF8 in cancer immunosurveillance. In comparison to immunocompetent (wild-type) hosts, interferon-regulatory factor 8 (IRF8)-deficient mice receiving B16.F10 melanoma cells exhibit accelerated tumor growth and an increased propensity to form lung metastasis. For the most part, this reflects the establishment of a highly immunosuppressive tumor microenvironment characterized by the expression of cytokines, chemokines, and pro-angiogenic factors that support tumor growth and metastasis. All these events are closely correlated with the epigenetic silencing of Irf8 in melanoma cells.
