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The immune landscape of human tumors

Implications for cancer immunotherapy

, , &
Article: e27456 | Received 29 Nov 2013, Accepted 07 Dec 2013, Published online: 03 Jan 2014

Figures & data

Figure 1. Immune contexture and mechanisms associated with patient’s prolonged survival. Schematic representation of tumors and major immune cells associated with the proper immune contexture. The tertiary lymphoid structure, TFH and B cell axis, through the production of CXCL13 and IL21 shapes with the chemokines CXCL9, CXCL10, CXCL11, CCL5, and CCL2, the memory, Th1 and cytotoxic T cell response.

Figure 1. Immune contexture and mechanisms associated with patient’s prolonged survival. Schematic representation of tumors and major immune cells associated with the proper immune contexture. The tertiary lymphoid structure, TFH and B cell axis, through the production of CXCL13 and IL21 shapes with the chemokines CXCL9, CXCL10, CXCL11, CCL5, and CCL2, the memory, Th1 and cytotoxic T cell response.