Figures & data
Figure 1. Cancer cell-extrinsic oncosuppressive functions of RB1. (A) The irradiation of osteoblasts with functional retinoblastoma 1 (RB1) results in the emission of an alarm signal that comprise (among other molecules) interleukin (IL)-1β, IL-6 and IL-8. This signal reinforces senescence in an autocrine or paracrine fashion, but also recruits immune cells, including natural killer T (NKT) cells. (B) In osteoblasts lacking RB1 irradiation fails to induce the secretion of IL-6 and the consequent recruitment of NKT cells, hence favoring oncogenesis.
