Figures & data
Figure 1. Role of interleukin-30 in the prostate cancer microenvironment. Interleukin-30 (IL-30) may be produced by cancer cells as well as by tumor-reactive cells of myeloid origin, such as monocytes, macrophages and myeloid-derived suppressor cells (MDSCs). These immune cells constitute the major source of IL-30 within the lymph nodes that drain metastatic prostate cancer lesions. IL-30 may act not only on cancer cells of both primary and metastatic tumor lesions, but also on local immune cells and other cell types endowed with appropriate receptors, hence displaying functions that are for the most part hitherto unknown.
