Figures & data
Figure 1. Schematic diagram of multi-functional core-shell nanoparticle. RAGE analog has the properties of targeting, recognizing and conjugating AGEs like RAGE, but without the ability of causing the signaling cascades.
Figure 2. The dual-target drug delivery system of the core-shell nanoparticle. (A) The morphology of core-shell nanoparticle when the AGEs in kidney are normal. (B) When the AGEs are excess in kidney, RAGE analog and endogenous RAGE will start a competitive conjugation with AGEs, which can block the AGE-RAGE signaling cascades indirectly, at the same time, the core-shell nanoparticle releases AGEs inhibitors to inhibit the intermediate product of AGEs. (C) The RAGE inhibitors release sequentially to suppress endogenous RAGE expression.
