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Organogenesis Volume 10, 2014 - Issue 1
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Review

The primary cilium

Guardian of organ development and homeostasis

Andrew M Fry Department of Biochemistry; University of Leicester; Leicester, UKCorrespondence[email protected]
,
Michelle J Leaper Department of Biochemistry; University of Leicester; Leicester, UK
&
Richard Bayliss Department of Biochemistry; University of Leicester; Leicester, UK
Pages 62-68 | Received 16 Apr 2014, Accepted 16 Apr 2014, Published online: 17 Apr 2014

Figures & data

Figure 1. A schematic overview of the primary cilium illustrating the signaling pathways that are controlled through this organelle, and the clinical phenotypes, organ involvement and syndromic ciliopathies associated with defects in primary cilium signaling. MKS, Meckel-Gruber Syndrome; JBTS, Joubert Syndrome: BBS, Bardet Biedl Syndrome; NPHP, nephronophthisis; OFD, Oral-Facial-Digital Syndrome; SLS, Senior-Løken Syndrome; AS, Alstrom Syndrome; SRPS, Short Rib-Polydactyly Syndrome; EVS, Ellis-van Creveld Syndrome.

Figure 1. A schematic overview of the primary cilium illustrating the signaling pathways that are controlled through this organelle, and the clinical phenotypes, organ involvement and syndromic ciliopathies associated with defects in primary cilium signaling. MKS, Meckel-Gruber Syndrome; JBTS, Joubert Syndrome: BBS, Bardet Biedl Syndrome; NPHP, nephronophthisis; OFD, Oral-Facial-Digital Syndrome; SLS, Senior-Løken Syndrome; AS, Alstrom Syndrome; SRPS, Short Rib-Polydactyly Syndrome; EVS, Ellis-van Creveld Syndrome.

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