Figures & data
Figure 1 A schematic overview of the appetite regulatory pathways in the adult hypothalamus. (From ref. Citation9 with permission.)
Figure 2 Autoradiographs depicting the distribution of POMC mRNA expression in the fetal ARC in saline infused (A) and glucose infused (B) fetuses at 140 ± 1 d gestation (term ∼150 d gestation). (C) The effect of glucose infusion on the expression of POMC mRNA in the fetal arcuate nucleus. * denotes p < 0.05 compared to the saline infused fetuses. ARC: arcuate nucleus, 3V: third ventricle.
Figure 3 Autroradiographs depicting typical patterns of OBRb expression in the fetal sheep at (A) 134 d gestation (B) 141 d gestation and (C) 30 d of postnatal age. (D) Graph depicting the ratio of expression of OBRb in the arcuate nucleus (ARC) and ventromedial hypothalamus (VMH) at 134 d gestation, 141 d gestation and 30 d of postnatal age. Different letters denote significant differences between age groups p < 0.05. ARC: arcuate nucleus, VMN: ventromedial hypothalamus, 3V: third ventricle.
Figure 4 Overview of our current working hypothesis on the pathway through which maternal overnutrition results in the programming of obesity in postnatal life.
